A person who is preparing to undergo a surgical procedure must stop taking the drug several days in advance, to eliminate it from the body and reduce the risk of excessive bleeding during the operation.īase drugs can be prepared in different ways to yield products that are effective for different lengths of time. For example, the blood thinner warfarin is prescribed to people who are at risk of developing blood clots. This is medically significant in many instances, because drugs can interact with one another, and because some can influence the success of a surgical operation. The longer a drug’s half-life is, the longer it takes for the body to eliminate a single dose. It is much more common, however, for a drug’s half-life to be measured in terms of hours and days. For example, biophosphonates, which are used to treat osteoporosis, are absorbed by bones and have half-lives that can extend for many years. Medications that are eliminated from blood plasma more slowly remain at effective doses for much longer periods of time, from days to weeks to months, and even longer.
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